Oklahoma defeated Missouri 17-6 in Week 13, with the Sooners' defense setting the tone throughout the contest. The home team built its lead quickly, scoring 14 points in the second quarter while holding Missouri scoreless through three quarters.

Beau Pribula led Missouri's passing attack with 231 yards, but the Tigers managed only two field goals—both in the first half—and struggled to find the end zone. Oklahoma's defense delivered crucial stops, including a pivotal fourth-quarter interception by E. Bowen that sealed the victory.

The game's most explosive play came in the second quarter when Oklahoma's J. Mateer connected with I. Sategna III on an 87-yard touchdown pass. John Mateer led Oklahoma's ground game with 60 rushing yards, while JaVonnie Gibson paced the receiving corps with eight catches.

The defensive battle remained competitive throughout, with 29 lead changes according to win probability metrics. Oklahoma covered the 4.5-point spread and the game finished well under the 42.5-point total, reflecting the defensive dominance that characterized this low-scoring matchup.